ABSTRACT

Background: The relations of adropin, and irisin concentrations to congestive heart failure (CHF) risk have not been comprehensively elucidated. We sought to study the markers of adropin, and irisin , both in control subjects and in CHF. Methods: The study registered thirty four patients with CHF and thirty four healthy group. Fasting venous blood samples were collected from all cases. Serum adropin and irisin levels were analyzed using ELISA method. For all comparisons, statistical significance was defined by p ≤ .05. Results: Adropin, total cholesterol, and triglycerides parameters were found significantly high (P< 0.001) with the exception of irisin, and high-density lipoprotein- C which was significantly low (P< 0.001) in CHF patients. Conclusion: The present work suggests a measurement of adropin and irisin level in serum samples is a potential marker for diagnosing of CHF. Keywords: Adropin and irisin, congestive heart failure.