ABSTRACT

Background: The aim of this study was to evaluate the prevalence and clinicopathological differences between type I and type II endometrial cancer.

Methods: This retrospective study was carried out on 480 histological confirmed endometrial cancer women (362 Type I and 118 Type II patients), diagnosed and treated in Imam Khomeini hospital from March 2010 to February 2021.

Results: The average age of these 480 patients was 55.94±10.19 with the age range of 27 to 84. Of them, 72.1% were post-menopausal and 13.5% were nulliparous. The two most common presentations of EC were post-menopausal vaginal bleeding and menometrorrhagia.

The three survival rate, and five survival rate was 382 (95.3%), and 271 (83.4%), respectively with significantly (p-value<0.001) higher proportion in three and five survival rate in Type II.

The survival rate based on tumor stages demonstrated a better rate in low stages compared to high stages. In addition, disease recurrence occurred in 17.1% (82) of patients with significant (p-value<0.001) more prevalent in Type II of tumor.

Conclusions: The findings of this study recommend that the higher mortality rate of type II endometrial cancer might be due to its high stage at the time of diagnosis. Accordingly, comprehensive screening is likely to increase the survival rate in this curable cancer.

Keywords: Endometrial cancer, Cancer stage, Prognosis, Survival