ABSTRACT

Aim: To compare the serum level of homocysteine and fibrinogen in patients with controlled and uncontrolled type 2 diabetes mellitus

Methods: It was a cross sectional study. Total 120 consented patients with age range 35-45 years were involved in this study. Patients were taken from LGH, Lahore General Hospital from 2016 August to January 2017. Grouping of patients was done on the values of HbA1c i.e. Group I included controlled diabetes with HbA1c <7 and Group II included uncontrolled diabetes with HbA1c >7. Level of blood HbA1c, fibrinogen and homocysteine were estimated by immunoturbidimetric, Clauss method and ELISA technique respectively

Results: Mean age of group I and II was 44 and 46 with BMI 25 and 27 kg /m2 respectively. Chronicity of DM in group I was 24 months and in group II was 49 months. Percentages of HbA1c was 6.25 in group I and 8.65 in group II. Level of fibrinogen and homocysteine was significantly high in group II as compared to group I. Conclusions: High level of fibrinogen along with homocysteine may be useful predictor of cardiovascular risk in uncontrolled diabetic people.

Keywords: Cardiovascular disease, Diabetes, fibrinogen, homocysteine