ABSTRACT

Background: Preeclampsia is the hypertensive pregnancy with hallmark of proteinuria. Assessment of various biochemical markers is important to differentiate and predict the severity of preeclampsia. 

Methodology: This was a comparative cross sectional study that recruited 125 pregnant women diagnosed with preeclampsia. There were 30 patients with mild and 95 with severe preeclampsia. The serum total bilirubin, alanine transaminase (ALT), gamma glutamyl transferase (GGT), alkaline phosphatase (ALP), total proteins and albumin levels were measured. 

Results: There were significant differences in gestational age, ALT, ALP, total proteins, albumin and globulin levels between mild and severe preeclampsia (P<0.05). However, significant association was not observed for age, serum total bilirubin and GGT between two groups.

Conclusion: The serum ALT, ALP, total proteins and albumin may provide sensitive measurement for the prediction of severity of preeclampsia.