ABSTRACT

Objective: To determine the association of Left ventricular diastolic dysfunction (LVDD) with uncontrolled hypertension.

Materials and methods: This case control study was done at cardiac department of Punjab Institute of Cardiology, Lahore. Study duration was six months from 24 November 2016 to 23 May 2017. Patients with uncontrolled and controlled hypertension, age between 20 and 70 years coming for echocardiography and either of gender were included. Blood pressure was measured after 5 minutes of resting sitting position. The average of 3 blood pressure readings taken at intervals of at least 1 minute, were taken as representing clinic blood pressure. Echocardiography was done and it is measures of E/A using pulsed Doppler technique at stage of the mitral valve leaflets tip were used to evaluate the absence or presence of diastolic dysfunction of the left ventricle. E wave deceleration time (DT), isovolumic relaxation time (IVRT) were also obtained at the same time. The threshold of <1.0 was used as an indication of reversed E/A ratio. Using above measured parameters LVDD assessed. All the information was collected via pre-designed study proforma.

Results: The mean age of cases group was 44.71±13.68 years and in control group was 47±13.68 years. Out of 160 patients the LVDD was found in 71(44.38%) patients. Statistically 11.68 times more risk of LVDD was found in case group than to control group. i. e OR [5.502-24.808].

Conclusion: The incidence of left ventricular diastolic dysfunction was observed to be frequently high among hypertensive patients as compared to controlled hypertensive individuals and doppler echocardiography is very useful tool in its diagnosis.