ABSTRACT

Objective: To detect the plasma fibrinogen levels in type 2 diabetes mellitus patients by taking non-diabetes healthy individuals as control and correlation between plasma fibrinogen levels and glycemic status. Methods: This case control study was conducted at department of Pathology NICVD Karachi, from November 2018 to November 2019. Diagnosed cases of type 2 DM of >18 years of age and irrespective of gender were included in the study and non-diabetic healthy individuals were taken as control. All the study subjects were assessed regarding glucose level, HbA1c level and Fibrinogen measurement. Data was collected via study proforma and analysis was done by using SPSS version 20. Results: Mean of fibrinogen level was 331.48±63.5 among diabetes group and mean fibrinogen level was 246.19±18.2 in non-diabetes group (p=<0.01). Average of hemoglobin A1c among type 2 diabetes cases and in non-diabetes cases was found to be 9.40±1.1 and 6.12±0.5 respectively (p=<0.01). Mean fibrinogen level was significantly associated with elevated glycemic status (p=<0.01). Average systolic blood pressure and diastolic blood pressure were also high among those who had Glycemic status (Hba1c) >8% (p=<0.01).

Conclusion: There was significant positive association of fibrinogen with glycemic status in type 2 DM patients. Keywords: Fibrinogen, hemoglobin A1c, type 2 diabetes mellitus