ABSTRACT

Objective: To assess the incidence of Sitagliptin-induced arthropathy in q`non-obese patients with diabetes mellitus type-2.

Methodology: A comparative cross-sectional study was done at the community of Sadder and Latifabad, Hyderabad, Sindh, Pakistan from July 2017 to March 2018. All diagnosed patients with diabetes mellitus aged above 18 years were eligible to partake in the study. For study Group A, patients with DM Type 2 with joint pain were included while for control group, patients with DM Type 2 without joint pain were included. The two groups were prescribed Sitagliptin as an add-on to the on-going treatment regime for diabetes mellitus type 2. Two sets of serology tests were obtained including CRP, Serum calcium, HbA1C at interval of 0 and 24th weeks. Two sets of X-rays of right knee and right wrist joints were obtained at 0 and 24th week.

Results: Hemoglobin A1c was significantly reduced (p=0.05) while there was insignificant alteration note in CRP and serum calcium the p value was 0.06 and 0.07. After sitagliptin use, 35 /68 (50%) had multiple radiological abnormalities seen, most common was reduced joint space and spur formation and p value was significant 0.04 and in control 10 /50 (20%), most common x ray abnormality was osteopenia. Conclusion: The occurrence of arthropathy was more common among patients using DPP-4 inhibitors as compared to non-users. It is only study as so far done in last couple of years to highlight Sitagliptin induced arthropathy.

Key words: CRP, Sitagliptin, arthropathy, Hyderabad