ABSTRACT

Background: With advancement in the field of medicine yet there is a need of non-invasive method for detecting fibrosis in patients suffering from chronic liver disease.

Aim: To find an agreement between Shear Wave Elastography and APRI & FIB-4 score in patients of CLD.

Study design: Descriptive, cross-sectional.

Methodology: The current project was conducted at department of Radiology, Shaukat Khanum Hospital, Lahore from 01-06-2019 to 1-12-2019. Current study comprised of 80 patients of both genders. Stages of fibrosis were defined on SWE. FIB-4 and APRI score were determined using serological markers. The collected data was analyzed by using SPSS version 24. Mean with standard deviation was calculated for age, AST, ALT, Platelet count.

Results: In our study, 62.5% were males while 37.5% were females. With mean age of 43.47 SD±13.85. APRI & FIB-4 scores predicted F4 patients using cutoff values of 0.47 (Sn. 72%, Sp. 70%) and 1.27 (Sn. 78%, Sp. 73%) respectively.

Conclusion: The diagnostic accuracy of FIB-4 for predicting liver fibrosis was better than that of APRI in all stages of liver fibrosis when compared with SWE.

Keywords: APRI, FIB-4, Liver Fibrosis, Chronic Liver Disease and Shear Wave Elastography