ABSTRACT

Background: Dietary fats lead to hyperlipidemia which causes multiple disorders. Vitamin D reduces serum lipid levels and prevents the development of hyperlipidemia.

Methodology: In this randomized control trial , 90 male albino mice were randomly taken into three groups with 30 mice in each group. Group A was given normal diet, group B high fat diet, group C high fat diet plus vitamin D (calcitriol, 100ng/kg per day) for 6 weeks. By the end of 6 weeks terminal blood sampling was taken. Serum was analysed for lipid profile by calorimetric method. Data was analysed by using SPSS version 20.

Results: Serum total cholesterol(TC), low density lipoproteins(LDL), very low density lipoproteins(VLDL) were all raised and high density lipoproteins (HDL) was reduced in high fat diet group B. TC, LDL, VLDL all were reduced and HDL was raised in high fat plus vitamin D group C as compared to group B.

Conclusion: Vitamin D prevents hyperlipidemia when administered along with high fat diet.

Keywords: Hyperlipidemia, Albino Mice and Vitamin D