Aims & Objective: This study was conducted to estimate the serum magnesium level in patients of type-II diabetes mellitus and diabetic nephropathy.

Methodology: This case control study was conducted at LUMHS Jamshoro Sindh Pakistan. Total 120 subjects were selected for this research divided in to three groups, control and two case study groups for the period of six months July 2020 to December 2020. FBS, HbA1%, serum creatinine, serum magnesium levels were estimated from all subjects. The statistical analysis was done by SPSS version 21 by applied ANOVA test to compare the parameters in different groups.

Results: Serum Magnesium level was significantly (p<0.05) decline in group C patients of diabetic nephropathy with poor glycemic control as compared to control or diabetic patients without complications.

Conclusion: Estimation of serum magnesium level in the diabetic patients can be use for the early predictor tool to know the expansion of diabetic complications.

Keywords: Type-2 Diabetes Mellitus, Diabetic Nephropathy, Serum Magnesium