Introduction: Childhood enuresis is a stressful condition for both family members and patients. Different strategies can be offered to manage this condition with variable success rates. Data on the treatment of enuresis are scarce Sudan. We compared the efficacy of treatment with albendazole, desmopressin, and a combination of these two medications.

Methodology: This was a prospective randomized hospital-based study Khartoum Children Hospital, Sudan. Children aged 5 15 years who presented with enuresis were recruited. Subjects were randomly assigned to one of three 3 treatment groups (albendazole, desmopressin, or combination therapy) using a computer-generated table. The participants, pharmacists, and clinicians were aware of the treatment received by each individual.

Results: A total of 71 children were enrolled; 34 (47.9%) were men and 37 (52.1%) were women. All participants were offered counseling, motivation, and toilet training. Albendazole was administered to 17 children, desmopressin to 17 patients, and combination therapy was offered to 20 patients.  Five patients initially responded to counselling, motivation, and toilet training. Nine of 17 (52.9%) patients responded well to albendazole, 8/17 (47.1%) responded to desmopressin, and finally, 15/20 (75%) responded to combined therapy. Twelve patients declined to continue the trial during non-pharmacological treatment.

Conclusion: Combined albendazole and desmopressin therapy seems to offer a better response in the treatment of children with enuresis.

Keywords: enuresis, albendazole, desmopressin, counseling, enterobias vermicularis