Role of Myo-inositol and D-Chiro-Inositol in Improvement of Endocrine and Clinical Parameters in Girls affected by PCOS
Rubeena Badar Khan, Muntiha Sarosh, Shehnaz Anwer
21
ABSTRACT
Aim: To evaluate the effectiveness of
Myo-inositol and D-chiro-Inositol combination therapy in improvement of
Endocrine and clinical parameters in teenage girls affected by PCOS.
Methods: This Prospective Cohort
study was conducted in the Department of Gynaecology & Obstetrics, Avicenna
Medical College and hospital after approval from Institutional ethical committee from January 2021 to June
2021. We have enrolled 106 teenage girls from 13 to 19 years with PCOS.
Baseline clinical, ultrasound and biochemical parameters were noted and
assigned them into two treatment groups (A & B) randomly. Group A was given
MI plus DCI and Group B was given placebo for 6 months. Differences were
analyzed in pretreatment and post treatment ultrasound findings and Clinical
variable of BMI, Acne, hirsutism and menstrual irregularities. Biochemical
parameters including LH:FSH ratio, 17-beta Estradiol and fasting glucose were
also evaluated in both groups. Statistical Analysis was done using SPSS version
21.
Results: A
statistically significant improvement was observed in clinical & Laboratory
parameters in treatment group showing reduced LH:FSH ratio, fasting glucose and
increased Estradiol levels along with decreased BMI, Acne and hair growth and improved
ultrasound parameters in same group as compared to placebo group.
Conclusion: The current study showed promising results of combined therapy with MI
plus DCI for treatment and improvement of clinical and lab parameters in teenage
girls affected with PCOs as compared to placebo.
Keywords: PCOS, Myo-inositol, D-chiro-inositol, Hirsutism, Acne.
ABSTRACT
Aim: To evaluate the effectiveness of
Myo-inositol and D-chiro-Inositol combination therapy in improvement of
Endocrine and clinical parameters in teenage girls affected by PCOS.
Methods: This Prospective Cohort
study was conducted in the Department of Gynaecology & Obstetrics, Avicenna
Medical College and hospital after approval from Institutional ethical committee from January 2021 to June
2021. We have enrolled 106 teenage girls from 13 to 19 years with PCOS.
Baseline clinical, ultrasound and biochemical parameters were noted and
assigned them into two treatment groups (A & B) randomly. Group A was given
MI plus DCI and Group B was given placebo for 6 months. Differences were
analyzed in pretreatment and post treatment ultrasound findings and Clinical
variable of BMI, Acne, hirsutism and menstrual irregularities. Biochemical
parameters including LH:FSH ratio, 17-beta Estradiol and fasting glucose were
also evaluated in both groups. Statistical Analysis was done using SPSS version
21.
Results: A
statistically significant improvement was observed in clinical & Laboratory
parameters in treatment group showing reduced LH:FSH ratio, fasting glucose and
increased Estradiol levels along with decreased BMI, Acne and hair growth and improved
ultrasound parameters in same group as compared to placebo group.
Conclusion: The current study showed promising results of combined therapy with MI
plus DCI for treatment and improvement of clinical and lab parameters in teenage
girls affected with PCOs as compared to placebo.
Keywords: PCOS, Myo-inositol, D-chiro-inositol, Hirsutism, Acne.