Frequency of Hypoparathyroidism in Children Presenting with Beta-Thalassemia Major in Tertiary Care Center
Ammara Manzoor, Naila Khizar, Nazia Bashir Abbasi, Muhammad Khalil, Sehrish Anjum, Shabana Asif
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ABSTRACT
Objective: Aim of our study is to determine the
prevalence of hypoparathyroidism in children presenting with beta-thalassemia
major in tertiary care center.
Study Design: Cross-sectional study
Place and Duration: The study was conducted at Thalassemia
Center Divisional Headquarter Hospital Mirpur Azad Kashmir during the period
from February 2021 to July 2021.
Methods: There were eighty eight children with both
genders had beta-thalassemia were presented in this study. Age of the patients
was between 5-14 years. We have obtained formal permission from the authorities
to collect full demographics, including age, sex, body mass index, chelation
and transfusion therapy, calcium consumption, the age of beginning of HPT, any
symptoms of hypocalcemia. Blood samples were taken for measurement of serum
calcium and phosphorus. Prevalence of hypoparathyroidism was calculated among
all the cases. SPSS 25.0 version was used to analyze all data.
Results: Majority of the patients were males 48 (60%)
and 32 (40%) females in this study. Mean body mass index was 7.12±3.13 kg/m2.
Mean age of the patients was 8.12±6.35 years. 45(56.3%) were on combination
therapy and chelation therapy was in 35 (43.7%). Mean serum calcium level was
6.17±3.55 mg/dl and phosphorus level was 4.15±9.97 mg/dl. We found frequency of
HPT among 18 (22.5%) cases.5.45±7.17 years was the mean age of beginning HPT. Patients
had HPT were mostly on single chelation therapy using deferiprone (DFP).There
was high prevalence of hypocalcemia found in 43 (53.8%) cases. Among 43 cases
of hypocalcemia, 24 (55.8%) patients were asymptomatic and 20 (44.2%) were
symptomatic in which paresthesias & numbness was the most common
complication.
Conclusion: We found in this study that the frequency of
hypoparathyroidism was a common complication in patients with beta-thalassemia.
Frequency of hypocalcemia was high among patients with most prevalent
asymptomatic cases. Paresthesias & numbness was the most common
complication among symptomatic hypocalcemia.
Keywords: Beta-thalassemia, Hypoparathyroidism,
Complications, Hypocalcemia
ABSTRACT
Objective: Aim of our study is to determine the
prevalence of hypoparathyroidism in children presenting with beta-thalassemia
major in tertiary care center.
Study Design: Cross-sectional study
Place and Duration: The study was conducted at Thalassemia
Center Divisional Headquarter Hospital Mirpur Azad Kashmir during the period
from February 2021 to July 2021.
Methods: There were eighty eight children with both
genders had beta-thalassemia were presented in this study. Age of the patients
was between 5-14 years. We have obtained formal permission from the authorities
to collect full demographics, including age, sex, body mass index, chelation
and transfusion therapy, calcium consumption, the age of beginning of HPT, any
symptoms of hypocalcemia. Blood samples were taken for measurement of serum
calcium and phosphorus. Prevalence of hypoparathyroidism was calculated among
all the cases. SPSS 25.0 version was used to analyze all data.
Results: Majority of the patients were males 48 (60%)
and 32 (40%) females in this study. Mean body mass index was 7.12±3.13 kg/m2.
Mean age of the patients was 8.12±6.35 years. 45(56.3%) were on combination
therapy and chelation therapy was in 35 (43.7%). Mean serum calcium level was
6.17±3.55 mg/dl and phosphorus level was 4.15±9.97 mg/dl. We found frequency of
HPT among 18 (22.5%) cases.5.45±7.17 years was the mean age of beginning HPT. Patients
had HPT were mostly on single chelation therapy using deferiprone (DFP).There
was high prevalence of hypocalcemia found in 43 (53.8%) cases. Among 43 cases
of hypocalcemia, 24 (55.8%) patients were asymptomatic and 20 (44.2%) were
symptomatic in which paresthesias & numbness was the most common
complication.
Conclusion: We found in this study that the frequency of
hypoparathyroidism was a common complication in patients with beta-thalassemia.
Frequency of hypocalcemia was high among patients with most prevalent
asymptomatic cases. Paresthesias & numbness was the most common
complication among symptomatic hypocalcemia.
Keywords: Beta-thalassemia, Hypoparathyroidism,
Complications, Hypocalcemia