Antibiotic Sensitivity Pattern in Blood Culture Positive Typhoid Fever
Farhana Ahmad, Ibrahim, Muhammad Shahid Ghaffar, Adnan Bashir, Sajid Shamim, Tahir Mahmood
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ABSTRACT
Objective: The aim of this study
is to determine the antibiotic sensitivity pattern in blood culture positive
typhoid fever.
Study Design:Retrospective study
Place and Duration:Children Medical Center (CMC) / Dr
Habib un Nabi Children Hospital Mingora Swat and Pediatrics department of
Hamdard University Hospital, Karachi for
the duration between June 2020 and December 2020.
Methods: There were total one hundred and twenty patients
of both genders were presented. Patients were aged between 5-15 years of age.
Patients detailed demographics age, sex and body mass index were recorded after
taking informed written consent. All the patients had fever. Blood sample of
all the patients were taken for salmonella species. The Kirby Bauer Disc
Diffusion method was used to test for antibiotic susceptibility, and the
results were interpreted in accordance with National Committee for Clinical
Laboratory Standards (NCCLS) guidelines. SPSS 20.0 version was used to analyze
complete data.
Results:There were 84 (70%) males and 36 (30%)
females. Mean age of the patients was 11.5±3.48 years. Among 120 cases of
salmonella, 89 (74.2%) were Salmonellatyphi and Salmonella paratyphi was found
in 31 (25.8%) patients. Sensitivity of antibiotics chloramphericol,
cotrimoxazole, and azithromycin was 100% greater than that of ciprofloxacin
and ofloxacin. (6.7%, vs 5.8%) But resistance of both antibiotics was
high. Nalidixic Acid showed 108 (90%) resistance to salmonella typhi.
Conclusion: We observed a very high degree of diversity
in the antimicrobial sensitivity pattern, with extremely high levels of
sensitivity to antibiotics that have been utilized in the past, such as
chloramphenicol and cotrimoxazole. It was discovered that the quinolones, which
were widely utilized in the last two decades, have a very poor sensitivity.
Keywords:Typhoid fever, Sensitivity, Antibiotics,
Resistance
ABSTRACT
Objective: The aim of this study
is to determine the antibiotic sensitivity pattern in blood culture positive
typhoid fever.
Study Design:Retrospective study
Place and Duration:Children Medical Center (CMC) / Dr
Habib un Nabi Children Hospital Mingora Swat and Pediatrics department of
Hamdard University Hospital, Karachi for
the duration between June 2020 and December 2020.
Methods: There were total one hundred and twenty patients
of both genders were presented. Patients were aged between 5-15 years of age.
Patients detailed demographics age, sex and body mass index were recorded after
taking informed written consent. All the patients had fever. Blood sample of
all the patients were taken for salmonella species. The Kirby Bauer Disc
Diffusion method was used to test for antibiotic susceptibility, and the
results were interpreted in accordance with National Committee for Clinical
Laboratory Standards (NCCLS) guidelines. SPSS 20.0 version was used to analyze
complete data.
Results:There were 84 (70%) males and 36 (30%)
females. Mean age of the patients was 11.5±3.48 years. Among 120 cases of
salmonella, 89 (74.2%) were Salmonellatyphi and Salmonella paratyphi was found
in 31 (25.8%) patients. Sensitivity of antibiotics chloramphericol,
cotrimoxazole, and azithromycin was 100% greater than that of ciprofloxacin
and ofloxacin. (6.7%, vs 5.8%) But resistance of both antibiotics was
high. Nalidixic Acid showed 108 (90%) resistance to salmonella typhi.
Conclusion: We observed a very high degree of diversity
in the antimicrobial sensitivity pattern, with extremely high levels of
sensitivity to antibiotics that have been utilized in the past, such as
chloramphenicol and cotrimoxazole. It was discovered that the quinolones, which
were widely utilized in the last two decades, have a very poor sensitivity.
Keywords:Typhoid fever, Sensitivity, Antibiotics,
Resistance