Analysis of Ultrasound as a Predictor of Renal Impairment in Patients with HCV Infection
Muhammad Shakil, Abdul Majid Mujahid, Farrukh Mahmood, Muhammad Asif, Muhammad Ilyas
782
ABSTRACT
Background:
Renal arterial waveform analysis done via
renal Duplex Doppler Ultrasound gives a safe, trustworthy, and real time
assessment of renal hemodynamics without any delay and ambiguity as it removes
various components that make estimation of renal function problematic.
Objective:
To evaluate the clinical validity of RI and
to identify the relationship between RI and RFT’s for evaluation of renal
function in patient. Analytical cross sectional examination was done at DHQ
teaching hospital Sargodha from 2020 to 2021. The it had 158 hepatitis C
positive patients and 79 healthy volunteers following approval of summary.
After validation of inclusion and exclusion criteria, patients were broken in
into 4 groups (A to D) according to stage of disease and controls were kept in
Group E. Grey scale ultrasonography test for renal measurements and renal
echogenicity was done. Sagittal and axial scans was done in supine posture from
anterior approach utilizing liver and spleen as an acoustic window. The size
and texture of liver was also assessed. Color Doppler was done to calculate
Resistive Index (RI) using conventional curvilinear probe.
Results:
The serum creatinine and urea levels in the
diseased groups were greater than those in the control group. It was
individuals in Group-D who had the highest creatinine levels, which were
followed by those in Groups C, B, and A, respectively. The greatest Urea level
was found in Group-D, at 49.6714.19, while the lowest was found in Group-A. The
mean RI in sick groups (the highest was in Group D, with values of 0.78 and
0.81 in the right and left kidneys, respectively) was similarly statistically
substantially greater.
Conclusion:
An important connection exists between RI and
RFT. The use of Doppler duplex ultrasonography for the study of renal
hemodynamics in cirrhotic patients with HCV is a reliable, non-invasive,
simple, immediate, and cost-effective method for examining renal hemodynamics
in these patients. It is not essential to have clinical symptoms or deviations
from RFTs for this test to be more accurate than RFTs at predicting disease
development.
Keywords: Renal Doppler Duplex Ultrasound, Renal Resistive Index (RI), Renal
function tests, Urea, Creatinine, Cirrhosis, HCV
ABSTRACT
Background:
Renal arterial waveform analysis done via
renal Duplex Doppler Ultrasound gives a safe, trustworthy, and real time
assessment of renal hemodynamics without any delay and ambiguity as it removes
various components that make estimation of renal function problematic.
Objective:
To evaluate the clinical validity of RI and
to identify the relationship between RI and RFT’s for evaluation of renal
function in patient. Analytical cross sectional examination was done at DHQ
teaching hospital Sargodha from 2020 to 2021. The it had 158 hepatitis C
positive patients and 79 healthy volunteers following approval of summary.
After validation of inclusion and exclusion criteria, patients were broken in
into 4 groups (A to D) according to stage of disease and controls were kept in
Group E. Grey scale ultrasonography test for renal measurements and renal
echogenicity was done. Sagittal and axial scans was done in supine posture from
anterior approach utilizing liver and spleen as an acoustic window. The size
and texture of liver was also assessed. Color Doppler was done to calculate
Resistive Index (RI) using conventional curvilinear probe.
Results:
The serum creatinine and urea levels in the
diseased groups were greater than those in the control group. It was
individuals in Group-D who had the highest creatinine levels, which were
followed by those in Groups C, B, and A, respectively. The greatest Urea level
was found in Group-D, at 49.6714.19, while the lowest was found in Group-A. The
mean RI in sick groups (the highest was in Group D, with values of 0.78 and
0.81 in the right and left kidneys, respectively) was similarly statistically
substantially greater.
Conclusion:
An important connection exists between RI and
RFT. The use of Doppler duplex ultrasonography for the study of renal
hemodynamics in cirrhotic patients with HCV is a reliable, non-invasive,
simple, immediate, and cost-effective method for examining renal hemodynamics
in these patients. It is not essential to have clinical symptoms or deviations
from RFTs for this test to be more accurate than RFTs at predicting disease
development.
Keywords: Renal Doppler Duplex Ultrasound, Renal Resistive Index (RI), Renal
function tests, Urea, Creatinine, Cirrhosis, HCV