Expression of Alpha Methyl Acyl-CoaRacemase (AMACR) Immunohistochemistry in Carcinoma Prostate in Tertiary Care Hospital
Mohammad Manzoor, Asim Muhammad, Adnan Sarwar, Mohibullah Khan, Inam-U-Llah, Hina Mir, Sudhair Abbas Bangash
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ABSTRACT
Objective: Prostate needle biopsy samples from cancer patients at a tertiary care
hospital were analysed for the presence of the potential screening indicator alpha-methylacyl-COA
RACEMES.
Material
and Methods: This was a Cross-sectional study carried out
at Department of Histopathology, Lady Reading Hospital Peshawar from June, 2021
to December, 2021.Regardless of the patient's age, tumour grade, or histological type,
all adenocarcinoma prostate specimens diagnosed at the Lady Reading Hospital
Peshawar on the basis of immunohistochemistry and routine histology were examined.
Standard and mean deviation were
computed for quantitative factors of patient like age and frequencies,
percentages were calculated for qualitative factors like AMACR expressions.
Results:
Outof 90 cases, AMACR positivity was found in 68
(85%), while negativity was seen in 22 (15%). Nine (11.3%) of the negative
cases had one staining (weak, non-circumferential) and three cases (3%) had no
stainings (No cytoplasmic staining).
Conclusion: Positive AMACR staining on prostate needle core necropsies may be
utilised to support a cancer diagnosis when the focus at issue is 1 mm in highest
diameter. Basic hematoxylin and eosin standards for malice require analysis of
cell-specific markers like P63 or 34E12. AMACR labelling must be interpreted in
the context of other labels that can be used to find out more.
Keywords: Adenocarcinoma of the
prostate, Alphamethylacyl-CoA racemase (AMACR), Immunohistochemistry
ABSTRACT
Objective: Prostate needle biopsy samples from cancer patients at a tertiary care
hospital were analysed for the presence of the potential screening indicator alpha-methylacyl-COA
RACEMES.
Material
and Methods: This was a Cross-sectional study carried out
at Department of Histopathology, Lady Reading Hospital Peshawar from June, 2021
to December, 2021.Regardless of the patient's age, tumour grade, or histological type,
all adenocarcinoma prostate specimens diagnosed at the Lady Reading Hospital
Peshawar on the basis of immunohistochemistry and routine histology were examined.
Standard and mean deviation were
computed for quantitative factors of patient like age and frequencies,
percentages were calculated for qualitative factors like AMACR expressions.
Results:
Outof 90 cases, AMACR positivity was found in 68
(85%), while negativity was seen in 22 (15%). Nine (11.3%) of the negative
cases had one staining (weak, non-circumferential) and three cases (3%) had no
stainings (No cytoplasmic staining).
Conclusion: Positive AMACR staining on prostate needle core necropsies may be
utilised to support a cancer diagnosis when the focus at issue is 1 mm in highest
diameter. Basic hematoxylin and eosin standards for malice require analysis of
cell-specific markers like P63 or 34E12. AMACR labelling must be interpreted in
the context of other labels that can be used to find out more.
Keywords: Adenocarcinoma of the
prostate, Alphamethylacyl-CoA racemase (AMACR), Immunohistochemistry