Association of Vitamin D Deficiency with Ischemic Cardiomyopathy among the Local Population of Pakistan
Muhammad Asif, Ammar Abdul Rahman, Areesha Shahid, Muhammad Ammar Arif
1268
ABSTRACT
Introduction: The
majority of the world's population is chronically deficient in vitamin D.
ergocalciferol (D2) and cholecalciferol (D3) are the two forms of vitamin D.
(D3). In terms of potency, vitamin D2 in the form of ergocalciferol (D2) is
superior to vitamin D3 (D3). It is possible to get ergocalciferol from herbal
sources, but cholecalciferol is produced in the body by being exposed to
ultraviolet B radiation on the skin (UVB). Vitamin D is made from
ergocalciferol, which is a precursor.
Objectives: Whether or if vitamin D deficiency is linked to ischemic cardiomyopathy
is the major purpose of this study (heart failure).
Material and methods: From August
to December 2021, researchers from Queen Mary University performed a
cross-sectional study. Participants were required to undergo physical exams,
blood tests, and echocardiographic evaluations as part of the research
procedure. Venous blood samples were obtained the next morning after subjects
had fasted the previous night (10 to 12 hours). After that, the serum was
centrifuged and sent to the laboratory for biochemical examination as quickly
as feasible.
Results: A total of 50 persons participated in this research, which depends on
data supplied by patients. There were no changes in age, gender, BMI, or sun
exposure between the two groups of subjects. In ICMP patients, calcium levels
were the only significant difference from those in the control group. Other
biochemical indicators did not vary substantially across subjects. As compared
to the general population, persons with ICMP had notably reduced mean 25(OH) D3
levels (14.5-7.4 ng/ml as opposed to 28.2-12.2; P = 0.001), but significantly
higher PTH and NT-proBNP concentrations. Conclusion: Vitamin D levels were
revealed to be lower in ICMP patients than in controls, and it was proved that
this shortfall had a major effect on heart function.
Keywords: Vit-D, Patients, Cardiac Functions, Cardiomyopathy
ABSTRACT
Introduction: The
majority of the world's population is chronically deficient in vitamin D.
ergocalciferol (D2) and cholecalciferol (D3) are the two forms of vitamin D.
(D3). In terms of potency, vitamin D2 in the form of ergocalciferol (D2) is
superior to vitamin D3 (D3). It is possible to get ergocalciferol from herbal
sources, but cholecalciferol is produced in the body by being exposed to
ultraviolet B radiation on the skin (UVB). Vitamin D is made from
ergocalciferol, which is a precursor.
Objectives: Whether or if vitamin D deficiency is linked to ischemic cardiomyopathy
is the major purpose of this study (heart failure).
Material and methods: From August
to December 2021, researchers from Queen Mary University performed a
cross-sectional study. Participants were required to undergo physical exams,
blood tests, and echocardiographic evaluations as part of the research
procedure. Venous blood samples were obtained the next morning after subjects
had fasted the previous night (10 to 12 hours). After that, the serum was
centrifuged and sent to the laboratory for biochemical examination as quickly
as feasible.
Results: A total of 50 persons participated in this research, which depends on
data supplied by patients. There were no changes in age, gender, BMI, or sun
exposure between the two groups of subjects. In ICMP patients, calcium levels
were the only significant difference from those in the control group. Other
biochemical indicators did not vary substantially across subjects. As compared
to the general population, persons with ICMP had notably reduced mean 25(OH) D3
levels (14.5-7.4 ng/ml as opposed to 28.2-12.2; P = 0.001), but significantly
higher PTH and NT-proBNP concentrations. Conclusion: Vitamin D levels were
revealed to be lower in ICMP patients than in controls, and it was proved that
this shortfall had a major effect on heart function.
Keywords: Vit-D, Patients, Cardiac Functions, Cardiomyopathy