Background: Chronic liver disease is associated with various skin manifestion. This study was done to assess the spectrum of dermatological changes in chronic liver disease.

Objective: To evaluate any correlation between the dermatological findings and the type of the liver diseases.

Material and Method: A total 100 patients of chronic liver disease due to any etiology were included after taking informed consent. This study was conducted at department of medicine and department of dermatology Shaheed Mohtarma Benazir Bhutto Medical University Larkana from january 2019 to june 2019.

Results: In our study total number of patients was 100, among them males were 70(70%) and females were 30 (30%),mean age of patients was 43 ± 17,duration of disease ranged from 1 to 11 years.Fifty patients (50%) were suffering from chronic HCV infection,47 patients were suffering from chronic HBV infection,03 patients were suffering from HCV and HBV infection. Differrent manifestations were terry ‘s nails(83%) xerosis (68%), hyperpigmentation (52%), pruritis (35%), palmer erythema (32%),Non scarring hair loss from axilla and groin (28%), Cutaneous infections (07%),lichen planus (04%), gynaecomastia (04%),spider naevi (03%), acralnecrolytic erythema (01%)

Conclusion: Patients with chronic liver disease can have a wide varietyof cutaneous manifestations which  can give a clue to the presence of the underlying liver disease and its severity .Therefore, identifying these signs earlier can lead to quick diagnosis and effective management of the underlying condition, hence preventing its complications.

Keywords: Dermatological Manifestations, Chronic liver disease