Efficacy of Intralesional Vitamin D3 Injection in Cutaneous Warts
Samreen Dost Shaikh, Naeem Ahmed Soomro, Shumaila Shaikh, Rakhi Kumari, Sorath Sohail, Irfan Ahmed Shaikh
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ABSTRACT
Background: Cutaneous warts are common dermatological
viral infection caused condition which causes cosmetic problems besides it
primary morbidity like pain and discomfort. Intralesional vitamin D3
derivatives therapy is recent and effective modality for treatment of cutaneous
warts.
Objective: To determine the efficacy of intralesional
vitamin D3 injection in cutaneous warts in local patients.
Methods and patients: A descriptive case series study
conducted from June to December 24, 2019 at Dermatology OPD, SMBBMU- Larkana.A
sample of 65 patients with cutaneous warts, either gender, age 20-50 years, 3
months to 6 months history were included after taking a valid informed/ written
consent.
Pregnant and lactating
women, patients on immunosuppersive therapy, signs of any systemic or local
inflammation or infection, history of pasthma allergic skin disorders
meningitis or convulsions, history of hypersensitivity to Vitamin D3 were
excluded. The injections of vitamin D3 (vials containing 6,00,000 IU of
cholecalciferol in 1 ml = 15 mg)were given at 2 weekly intervals for a maximum
of four injections.A standard questionnaire was used to collect demographic and
study related data. Data analysis was
performed through SPSS Version-21. Descriptive and inferential
statistics were calculated. Stratification was done and post stratification chi
square test was applied. P-value ≤0.05 was considered as significant.
Results:
The
mean age of patients was 27.9±5.1 with C.I (26.63-29.16) years. The Mean ± SD
of duration was 4.4±1.9 with C.I (3.92-4.87) months. The Mean ± SD of number of
warts was 14.3±4.2 with C.I (13.25-15.34). Out of 65 patients, 35 (53.8%) were
malewhile 25 (38.5%) patients were belong to urban areas. Primary outcome of
this study i-e; the efficacy was n=54 (83.1%). Stratified analysis revealed
that younger age (20 – 30 years), male gender, urban residence, 3-5 mm size,
2-3 months duration (p value = 0.009) were associated with more efficacy of
intralesional vitamin D3 injection in cutaneous warts.
Conclusion:This study clearly
demonstrates that recalcitrant plantar warts can be treated successfully with
intralesional vitamin D3 injection. The immunotherapy of injection vitamin D3
has better patient compliance, good therapeutic response without cosmetic
disfigurement and capable of preventing recurrences.
Keywords: Efficacy,
Intralesional Vitamin D3, Cutaneous Warts, Treatment,Immunotherapy.
ABSTRACT
Background: Cutaneous warts are common dermatological
viral infection caused condition which causes cosmetic problems besides it
primary morbidity like pain and discomfort. Intralesional vitamin D3
derivatives therapy is recent and effective modality for treatment of cutaneous
warts.
Objective: To determine the efficacy of intralesional
vitamin D3 injection in cutaneous warts in local patients.
Methods and patients: A descriptive case series study
conducted from June to December 24, 2019 at Dermatology OPD, SMBBMU- Larkana.A
sample of 65 patients with cutaneous warts, either gender, age 20-50 years, 3
months to 6 months history were included after taking a valid informed/ written
consent.
Pregnant and lactating
women, patients on immunosuppersive therapy, signs of any systemic or local
inflammation or infection, history of pasthma allergic skin disorders
meningitis or convulsions, history of hypersensitivity to Vitamin D3 were
excluded. The injections of vitamin D3 (vials containing 6,00,000 IU of
cholecalciferol in 1 ml = 15 mg)were given at 2 weekly intervals for a maximum
of four injections.A standard questionnaire was used to collect demographic and
study related data. Data analysis was
performed through SPSS Version-21. Descriptive and inferential
statistics were calculated. Stratification was done and post stratification chi
square test was applied. P-value ≤0.05 was considered as significant.
Results:
The
mean age of patients was 27.9±5.1 with C.I (26.63-29.16) years. The Mean ± SD
of duration was 4.4±1.9 with C.I (3.92-4.87) months. The Mean ± SD of number of
warts was 14.3±4.2 with C.I (13.25-15.34). Out of 65 patients, 35 (53.8%) were
malewhile 25 (38.5%) patients were belong to urban areas. Primary outcome of
this study i-e; the efficacy was n=54 (83.1%). Stratified analysis revealed
that younger age (20 – 30 years), male gender, urban residence, 3-5 mm size,
2-3 months duration (p value = 0.009) were associated with more efficacy of
intralesional vitamin D3 injection in cutaneous warts.
Conclusion:This study clearly
demonstrates that recalcitrant plantar warts can be treated successfully with
intralesional vitamin D3 injection. The immunotherapy of injection vitamin D3
has better patient compliance, good therapeutic response without cosmetic
disfigurement and capable of preventing recurrences.
Keywords: Efficacy,
Intralesional Vitamin D3, Cutaneous Warts, Treatment,Immunotherapy.