Prevalence of Diabetes Mellitus and Impaired Glucose Tolerance in Patients with Covid-19
Kashif Ali Samin, Sami Ullah, Zahra Amjad, Arjan Kumar, Uzma Jabbar, Muhammad Tahir Ibrahim
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ABSTRACT
Objective: The aim of this study is to determine the
prevalence of diabetes mellitus and impaired glucose tolerance in patients with
COVID-19.
Study Design:Cross-sectional study
Place and Duration:Conducted at department of Medicine,
Khyber Teaching Hospital (KTH),Peshawer and Avicenna Teaching Hospital,
Lahorefor the duration from July 2020 to December 2020.
Methods: There were one hundred and fifteen patients
of both genders had coronavirus disease were included in this study.Patients
ranged in age from 25 to 80 years.After obtaining informed written permission,
we collected detailed demographic information on all of the registered
patients, including their age, gender, BMI, educational attainment and place of
residence. All of the patients had their blood tested for corona disease using
RT-PCR. After screening positive (fasting capillary glucose >100 mg/dl and
200 mg/dl) and each sixth consecutive negative (fasting capillary glucose
<100 mg/dl) subjects, the 75-g oral glucose tolerance test was administered.
The SPSS 23.0 software was used for analyzing of data.
Results:Included patients had mean age 59.4±12.55
years with mean body mass index 29.12±11.76 kg/m2. There were 70
(60.9%) male patients and 45 (38.1%) females. Majority of the patients were
illiterate 65 (56.5%) and 49 (42.6%) patients were from urban areas. Most
common co-morbidities were hypertension, hyperlipidemia, chronic kidney disease
and coronary artery disease. We found 62 (53.9%) patients had diabetes mellitus
in which majority of the cases were pre-existing. Frequency of impaired glucose
tolerance was found among 26 (22.6%) cases in which majority of the cases had
pancreatic cancer. 28 (24.4%) cases had intubation. Overall mortality was found
among 18 (15.3%) cases.
Conclusion:This research found that people with diabetes
and poor glucose metabolism are more likely to have severe Covid-19. A
previously undiagnosed symptom of primary infection has been linked to a
disorder in glucose metabolism. Pathways through which SARS-CoV-2 affects
glucose metabolism must be investigated if disease aetiology is to be fully
understood.
Keywords:Coronavirus, DM, IGT, Co-morbidities,
Mortality
ABSTRACT
Objective: The aim of this study is to determine the
prevalence of diabetes mellitus and impaired glucose tolerance in patients with
COVID-19.
Study Design:Cross-sectional study
Place and Duration:Conducted at department of Medicine,
Khyber Teaching Hospital (KTH),Peshawer and Avicenna Teaching Hospital,
Lahorefor the duration from July 2020 to December 2020.
Methods: There were one hundred and fifteen patients
of both genders had coronavirus disease were included in this study.Patients
ranged in age from 25 to 80 years.After obtaining informed written permission,
we collected detailed demographic information on all of the registered
patients, including their age, gender, BMI, educational attainment and place of
residence. All of the patients had their blood tested for corona disease using
RT-PCR. After screening positive (fasting capillary glucose >100 mg/dl and
200 mg/dl) and each sixth consecutive negative (fasting capillary glucose
<100 mg/dl) subjects, the 75-g oral glucose tolerance test was administered.
The SPSS 23.0 software was used for analyzing of data.
Results:Included patients had mean age 59.4±12.55
years with mean body mass index 29.12±11.76 kg/m2. There were 70
(60.9%) male patients and 45 (38.1%) females. Majority of the patients were
illiterate 65 (56.5%) and 49 (42.6%) patients were from urban areas. Most
common co-morbidities were hypertension, hyperlipidemia, chronic kidney disease
and coronary artery disease. We found 62 (53.9%) patients had diabetes mellitus
in which majority of the cases were pre-existing. Frequency of impaired glucose
tolerance was found among 26 (22.6%) cases in which majority of the cases had
pancreatic cancer. 28 (24.4%) cases had intubation. Overall mortality was found
among 18 (15.3%) cases.
Conclusion:This research found that people with diabetes
and poor glucose metabolism are more likely to have severe Covid-19. A
previously undiagnosed symptom of primary infection has been linked to a
disorder in glucose metabolism. Pathways through which SARS-CoV-2 affects
glucose metabolism must be investigated if disease aetiology is to be fully
understood.
Keywords:Coronavirus, DM, IGT, Co-morbidities,
Mortality