Biochemical and Haematological Manifestations as Predictor for Covid-19: A Case-Control Study
Sher Aziz, Abdullah, Saqib Marwat, Muhammad Asif Zeb, Aman Ullah
1013
ABSTRACT
Background: Corona virus causes severe pneumonia of
idiopathic nature. The clinical manifestation ranges from mild to severe
respiratory problems. Due presences of target receptors and the release of
chemical mediators, it also affect other organs including the liver and kidney.
Objective: The purpose of this study was to determine
the effect of COVID-19 infection on hematological parameters, liver function
and renal function.
Methods: This multicenter case-control observational
study was conducted at Lady reading hospital, Hayatabad medical complex and
Khyber teaching hospital Peshawar. A total of 340 samples were processed
including 170 COVID-19 patients and 170 control groups. Complete blood count,
liver function tests and renal function tests were performed to determine the
effect of COVID infection on these parameters. The data were statistically
analyzed using SPSS version 22.0.
Results: In complete blood count, the mean WBC count
was 16632.34±7339.94 which was
statistically significant with p value less than 0.05. In differential
leukocyte count, the mean neutrophil values were 87.79±7.36 which was
statistically significant (p=0.00). The mean value of ALT and ALP were
49.47±100.08, 114.43±64.71 respectively which were higher than the control group.
Mean value of urea and creatinine were 70.58±41.89, 1.31±1.12 respectively and
was statistically significant (p=0.00).
Conclusion: it is concluded that COVID-19 infection affects
hematological and biochemical parameters including ALT, ALP, urea and
creatinine. Hence these manifestations can be used collectively as a diagnostic
and prognostic biomarker.
Keywords: Covid-19, liver function tests, Kidney
Function Tests, blood cell count
ABSTRACT
Background: Corona virus causes severe pneumonia of
idiopathic nature. The clinical manifestation ranges from mild to severe
respiratory problems. Due presences of target receptors and the release of
chemical mediators, it also affect other organs including the liver and kidney.
Objective: The purpose of this study was to determine
the effect of COVID-19 infection on hematological parameters, liver function
and renal function.
Methods: This multicenter case-control observational
study was conducted at Lady reading hospital, Hayatabad medical complex and
Khyber teaching hospital Peshawar. A total of 340 samples were processed
including 170 COVID-19 patients and 170 control groups. Complete blood count,
liver function tests and renal function tests were performed to determine the
effect of COVID infection on these parameters. The data were statistically
analyzed using SPSS version 22.0.
Results: In complete blood count, the mean WBC count
was 16632.34±7339.94 which was
statistically significant with p value less than 0.05. In differential
leukocyte count, the mean neutrophil values were 87.79±7.36 which was
statistically significant (p=0.00). The mean value of ALT and ALP were
49.47±100.08, 114.43±64.71 respectively which were higher than the control group.
Mean value of urea and creatinine were 70.58±41.89, 1.31±1.12 respectively and
was statistically significant (p=0.00).
Conclusion: it is concluded that COVID-19 infection affects
hematological and biochemical parameters including ALT, ALP, urea and
creatinine. Hence these manifestations can be used collectively as a diagnostic
and prognostic biomarker.
Keywords: Covid-19, liver function tests, Kidney
Function Tests, blood cell count