Objective: To compare the psychological disorders between vaccinated and unvaccinated patients with covid-19 disease.

Study Design: Retrospective/observational

Place and Duration: The study was conducted at Psychiatry department of Qazi Hussain Ahmed Medical Complex, Nowshera during the period of six months from December 2020 to May 2021.

Methods: Total 120 patients of both genders presented with covid-19 were included in this study. Patients’ detailed demographics including age, sex, BMI, vaccination status, and clinical presentation were recorded after taking written informed consent. Patients were aged between 15-60 years. Patients were equally divided into two groups. Group A (Vaccinated) had 60 and group B (Unvaccinated) contains 60 patients with covid-19 disease. Prevalence of depression and anxiety were measured by DASH-21 scale among both groups. Complete data was analyzed by SPSS 24.0 version.

Results: There were 40 (66.67%) males and 20 (33.33%) patients were females in group A. In group B 42 (70%) were males while 18 (30%) were females. Mean age of the patients in group A was 40.66 ±10.22 years with mean BMI 27.28±2.34 kg/m² and in group B, mean age was 41.16 ±9.42 years with mean BMI 28.14±2.48 kg/m². Frequency of depression and anxiety were high in unvaccinated patients 35 (58.33%) and 19 (31.67%) as compared to vaccinated patients, found in 20 (33.33%) and 10 (16.67%) patients. A significant difference was observed regarding depression and anxiety between vaccinated and unvaccinated patients. (P-value <0.05)

Conclusion: Psychological disorders such as depression and anxiety were significantly associated with unvaccinated patients with covid-19 disease.