Objective: The aim of this study is to compare the outcomes of amoxicillin and cephedrine in oral and dental

infections.

Study Design: Observational/ Comparative study

Place and Duration: Riphah International University, Almizan Campus, Rawalpindi/ Nayab Dental Clinic

Rawalpindi. January 2021 to Aug 2021.

Methods: Total one hundred and fifty patients of both genders were presented in this study. Demographically

detailed of included patients age, sex, cause of infection, residency and education status were calculated after

taking informed written consent. Patients had oral and dental infection and did not receive any treatment yet were

included. Patients were equally categorized into two groups. Group A had 75 patients and received 500mg

amoxicillin while group B had 75 patients treated with 500mg cephredine thrice a day for 5 days. Post-treatment

effectiveness among both groups was assessed and compared. SPSS 22.0 version was used to analyze the

complete data.

Results: There were 40 (53.3%) males and 35 (46.7%) females in group A while in group B 38 (50.7%) males

and 37 (49.3%) females. Mean age in group A was 34.13±12.42 years and in group B mean age was

35.04±11.31 years. 100 (66.7%) cases were from urban area (50 in each group). 88 (58.7%) patients were literate

(44 in each group). Gingivitis was found in 33 (44%) cases in group A and 35 (46.7%) in group B while frequency

of periodontitis was 37 (56%) in group A and 40 (53.2%) in group B. Smoking was the most common cause of

infection followed by compromised oral hygiene and diabetes. Post treatment frequency of effectiveness in group

B was higher among 63 (84%) cases as compared to group A. Frequency of adverse outcomes stomach upset,

diarrhea and dizziness were lower in group B. Change of dose frequently noted in group A among 15 (20%)

cases as compared to group B 8 (10.7%).

Conclusion: We concluded in this study that use of antibiotics in cure of dental and oral infections were effective

and useful but amoxicillin was significantly superior to cephredine with less number of adverse outcomes and

higher frequency of germs controlled.

Keywords: Dental Infection, Amoxicillin, Cephredine, Gingivitis, Periodontitis