Background and Aims: Rheumatologic disorders (RDs) can manifest as gastrointestinal (GI) symptoms.

Patients with systemic sclerosis (SSc) frequently experience upper GI symptoms due to a lack of esophageal

contractility (AC). GORD (gastro oesophageal reflux disease) is a common comorbidity in rheumatoid arthritis

patients (RA).The aim of the present study was to evaluate the correlation between manifestation of rheumatoid

arthritis and gastrooesophageal reflux disease.

Materials and Methods: This cross-sectional study was carried out on 845 gastro-oesophageal reflux disease

patients who presented to department of medicine, Qazi Hussain Ahmad Medical Complex Nowshera and Lady

Reading Hospital (LRH), Peshawar for period of six months i.e from January 2020 to June 2020. Consecutive

patients with were premeditated subsequently taking written informed consent. Patients with prior history of

Oesophageal surgery were excluded. The demographics characteristics such as age, BMI, gender, previous

history, gastrointestinal symptoms severity, analgesics, and medication usage were recorded on a pre-designed

questionnaire. Inflammatory marker’s results were taken in the forms of C - reactive protein (CRP), and

Erythrocyte Sedimentation Rate (ESR). Ethical approval was taken from the respective institutional review board.

SPSS version 20 was used for data analysis.

Results: Out of 845 GORD patients, 110 (13%) had Rheumatologic disorders (mean age 49.5± 2.6 years, 71%

females). The prevalence of rheumatoid arthritis (RA), systemic lupus erythematous (SLE), and the most common

systemic sclerosis (SSc) were 39 (36%), 24 (21.8%), and 47 (42.2%) respectively. Regurgitation, dysphagia,

heartburn, and nausea were the most severe symptoms of gastrointestinal patients having rheumatoid disorder.

The GI symptoms had no significant association with SLE, RA, and SSc severity. Upper GI symptom severity did

not differentiate between RDs.

Conclusion: Our study concluded that subsequent rheumatoid arthritis has a significant association with gastrooesophageal

reflux disease.

Keywords: Gastro-oesophagealReflux Disease, Rheumatoid arthritis, Systemic sclerosis