Role of Oral Tranexamic Acid in Treating Patients of Melasma in A Charity Hospital of Lahore
Mariam Sheikh, Ikram ur Rahim, Muhammad Latif, Rabail Majeed, Muhammad Awais, Sunila Riaz
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ABSTRACT
Objective: To evaluate the efficacy and safety of oral
tranexamic acid (TA) in the treatment of melasma
Method: This was a descriptive, cross sectional
study which was performed in department of dermatology in Akhtar Saeed Trust
Hospital, Lahore from April till December 2019. 70 patients of moderate to
severe melasma were enrolled regardless of gender, > 18 years of age. 250 mg
oral TA was given BD for 3 months along with broad spectrum topical sunscreen.
Follow up done on monthly basis, 2 months after stopping the treatment.
Photographs were taken at first visit & MASI (melasma area severity index)
scoring done at start & after 3 months of treatment. Side effects were
noted down if present. Results were recorded & analysed using SPSS.
Results: A total of 70
patients were enrolled, 44 females and 26 males. Mean age of patients was
30.7. There was a significant decrease mean 3.4 in MASI scoring at 12 wks of
treatment. 25 patients had good, 22 had fair, 7 had fair response to TA. No
serious side effects were noted at end of treatment. No reversal of melasma was
recorded at 2 months after stopping treatment.
Conclusion: Oral tranexamic acid is a
quick & effective treatment of patients of melasma.
Key words: Melasma, tranexamic acid,
treatment.