Background One of the most potent glucocorticoids is known as Dexamethasone. Many metabolic side effect shave been

reported on almost every organ after dexamethasone treatment specially its effect on liver.

Aim: To investigate harmful side effects of dexamethasone sodium phosphate on rabbit’s liver that serve as human liver

model via using light microscope, by administration of two doses (extreme) and two durations in order to depict the duration

as well as dosage dependency.

Methods: Liver samples were taken via rabbits who were administered dexamethasone sodium phosphate. Then two Stratas

were made namely, 1 and 2. The fixations of liver samples were carried out and underwent into evaluation in order to observe

any histochemical and histological alterations. Study duration is from February to May 2021 Rabbits were brought from

Veterinary Research Institute, Lahore. These Rabbits were kept in cages in the animal house of PGMI, Bird wood road Lahore.

Results: The ballooning and vacuolation of hepatic cells were seen in the liver in case of Stratas that were treated along with

the degenerative alterations of these cells, congestion and dilatation of central hepatic vein with sinusoidal capillaries, positive

periodic acid schiff's stain (PAS) reactions. The severity of all these alterations was dependent upon duration and dosage.

Conclusion: Morphological variations induced in the liver by dexamethasone sodium phosphate could be accepted as side

effects of these drugs.

Keywords: Liver, dexamethasone, histology, glycogen