Background: One of the leading causes for hepatocellular carcinoma is Nonalcoholic fatty liver diseases (NAFLD) that also

increases incidence of mortality rates.

Aim: To understand alterations biochemically and clinically in patients suffering from NAFLD since they are at stake of cirrhosis

as well as nonalcoholic steatohepatitis (NASH) in case of Pakistani population.

Methods: Patients suffering from NAFLD were selected for these case reaches that were all confirmed via ultrasonography.

Candidates were tested negative for autoimmune or viral hepatitis serologic markers, no record was found with respect to liver

disease related to metabolism, moreover candidates were also not administer any medication that has its impact on liver like

Ursobil. Clinically and biochemically all the patients were tested for history, signs and symptoms and they depicted variables.

Results: A enrollment of 80 candidates was carried out that included 38 female and 42 male, owing mean age of 40.4 years.

The candidates with no diabetes and obesity were 26.4% and 18.3%, respectively. Late dinner sleep disorders and delayed

sleep were the most detectable reasons in patients suffering from NAFLD. Moreover, thirst sensation, anxiety, bloating, and

upper abdominal pain, warming sensation and defecation disturbances, were seen common in case of patients suffering from

NAFLD.

Conclusion: NAFLD is regarded as heterogeneous pathology with variety of clinical findings. It has been experienced that

gastrointestinal problems as well as anxiety are most frequently seen in patients suffering from NAFLD.

Keywords: NAFLD, hepatocellular carcinoma, cirrhosis