Muhammad Muddasser Khan Panezai, Shahzad Gul, Zia Ehsan Kakar, Uzma Rasheed, Shazia Zammurad, Saira Tahir

Comparison of NSAIDS Versus NSAIDS Plus Duloxetine in Knee Osteoarthritis Patients

Muhammad Muddasser Khan Panezai, Shahzad Gul, Zia Ehsan Kakar, Uzma Rasheed, Shazia Zammurad, Saira Tahir



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ABSTRACT

Objective: To compare the efficacy of Duloxetine with NSAIDS versus NSAIDS alone for the treatment of knee pain secondary to osteoarthritis.

Study Design: Randomized clinical trial study.

Setting and Duration: Department of Rheumatology, PIMS Hospital, Islamabad, from April to August 2021.

Methodology: One hundred and twenty eight patients with knee osteoarthritis were included in the study and were divided in two equal groups; one group was subjected to Duloxetine plus NSAIDs and other to just NSAIDs. The response was assessed at end of 3 months. Reduction in pain more than or equal to 50% from the baseline was considered as efficacy.

Results: The mean VAS score was 3.56±1.15 in group A (Duloexetine plus NSAIDS) A while in group B (NSAID alone), 4.45±1.22 and significantly (p-value > 0.05). Similarly, the comparison of WOMAC score for pain showed that the mean WOMAC score was significantly (P-value > 0.05) less 5.68±1.56 in group A in contrast to 6.39 ± 1.69 in group B. Comparison of efficacy between two groups showed that the rate of efficacy was significantly (P-value >0.05) higher in group A 48.4% as compared to 31.3% in group B.

Conclusion: Addition of Duloxetine to NSAIDs resulted in more reduction of pain in terms of VAS and WOMAC score with acceptable adverse effects.

Keywords: Chronic pain, Duloxetine, Knee pain, NSAIDs, Osteoarthritis



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