Comparison of Efficacy of Ondansetron Pre-treatment in Alleviating Pain due to Propofol during General Anaesthesia with Placebo
Haneen Zahra, Abdul Bary, Tahir Nazeer, Saira Naseem, Muhammad Abdul Aziz, Riaz Hussain, Amna Tahir
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ABSTRACT
Background: Ondansetron is a 5HT3 receptor
blocker and has multifaceted action like sodium channel blocker and µ - opioid
agonist.
Objective: To compare the efficiency of
ondansetron pre-treatment in alleviating pain caused by propofol during
induction of general anaesthesia with placebo.
Material &
Method: In this randomized
controlled trail 120 patients of ASA grade I & II undergoing elective
surgery were included and divided into two equal groups A & B by using
lottery method. Each group comprised of 60 patients. In group A two ml 0.9 % normal
saline and in group B, 2 ml ondansetron (4mg) given intravenously. In both
groups propofol was given in a dose of 2.5 mg / Kg intravenously.
Results: The mean age of patients in group
A was 29.95 ± 4.79 year and in group B was 30.30 ± 4.87 year. Majority of
patients 67(55.83 %) were between 18 to 30 year of age. Out of 120 patients. 63
(52.50 %) were ASA I & 52 (47.50 %) were ASA II. Efficacy of group A (placebo)
was seen in 11 (18.33 %) while in group B (ondansetron) was seen in 56 (93.33
%).
Conclusion: Ondansetron pre-treatment in
alleviating pain cause by propofol is very effective.
Keywords: Pain, ondansetron, propofol,
general anaesthesia.