Aim: To estimate the effectiveness of lower limb exercise regime in subjects with knee osteoarthritis in terms of Kinesiophobia.

Methodology: This was a case series, conducted in the Physiotherapy Department Health Centre University of the Punjab Lahore after ethical approval from June 2018 to February 2019 on 44 patients with knee Osteoarthritis. Non-probability purposive sampling technique was used to enroll the participants according to predefined inclusion and exclusion criteria. Lower limb exercise regime was applied for eight weeks, thrice a week. TAMPA scale for Kinesiophobia (TSK), KOOS and 6 min walk test (6MWT) were used to measure the outcomes. Paired sample T test was applied to find the difference before and after LLEP. Statistical significance was set at P= 0.05

Results: Mean age of the participants was 52±6.54 years ranging from 41-65 years. The mean difference in pre and post treatment KOOS Score was 15.13±12.38 (P=.000), 14.34±7.97 (P=.000) for TAMPA Score and 196.00±94.01 (P=.000) for 6 Mint walk distance.

Conclusion: Lower limb exercise program is found effective in the management of knee osteoarthritis. Subjects undergoing in 8 weeks lower limb exercise program showed improvement in KOOS Score, reduction in TAMPA Score, and improvement in 6 mint walk distance.

Keywords: Knee Osteoarthritis, Kinesiophobia, TAMPA, knee osteoarthritis outcome score (KOOS), Lower limb exercise regime,