Objective: To determine the in-hospital outcomes after primary percutaneous coronary intervention (PCI) of patients with acute ST-segment elevation myocardial infarction (STEMI) and develop sustained ventricular arrhythmia before revascularization.

Methodology: This prospective observational study was conducted at the Department of Adult Cardiology, National Institute of Cardiovascular Diseases, from August 31, 2019, to February 29, 2020. All patients with STEMI who had developed sustained ventricular arrhythmias and underwent revascularization via primary PCI were included. The patients were kept under observation during their hospital stay to document in-hospital mortality. Data analysis was done using SPSS version 20.

Results: Total 146 patients were included with a mean age of 54.41±12.75 years. There were 93 (63.7%) males and 53 (36.3%) females.  When risk factors were assessed, hypertension was noted in 82 (56.2%) patients, diabetes mellitus in 62 (42.5%), 65 (44.5%) were smokers., and 49 (33.6%) were obese. There were 53 (36.3%) patients with a family history of ischemic heart disease. In-hospital mortality was documented in 28 (19.2%) patients. When stratification was done, significant associations were seen with hypertension (p=0.025), diabetes mellitus (p=0.002), and family history (p=0.003).

Conclusion: It is to be concluded that mortality is considerably high after PCI in patients with STEMI who developed sustained ventricular arrhythmia before revascularization. Obesity, family history, and diabetes contribute directly to the development of MI. More epidemiological studies are necessary to evaluate risk factors of in-hospital mortality in this already compromised group of patients

Keywords: Revascularization, Myocardial Infarction, Sustained Ventricular Arrhythmias, ST-Segment