Background: Ovulation induction with clomiphene citrate in women with infertility has been practiced  more than 40% years  but in infertile patients this treatment plan proved to be ineffective with multiple complication. Body weight plays an important role modulating reproductive development and functioning.

Aim: To observe the effects on body weight of female albino rat after use of clomiphene citrate and letrozole for consecutive 1-4 estrous cycles

Method: Eighty four adult female Albino rats were equally divided into three groups for this research. Body weight of each rat was measured before and after the experiment.  Vaginal smear cytology of each rat was performed to study different phases of estrous cycle. Control group A was given normal saline orally  , In Experimental group B  rats were given letrozole (Femara) at dose 5mg/kg orally and in Experimental  group C  rats were given clomiphene citrate at dose 100ug/kg orally.

Results: Significant weight gain is observed in rats taking clomiphene citrate as compared to letrozole

Conclusion : Comiphene citrate directly affects the body weight  which indirectly reduces the ovulation induction and pregnancy rate. Letrozole is good  alternate for ovulation induction and for CC resistant patients.