Aim: To compare metformin vs insulin in Gestational Diabetes in terms of neonatal hypoglycemia.

Methodology:

Study design: Randomized controlled trial

Setting: Obstetrics / Gynecology Unit-l, Holy Family Hospital, Rawalpindi.

Duration of study: 6 months i.e. 10-11-2017 to 10-05-2018

Data collection procedure: 240 patients were randomly allotted into two groups; A & B. Group A received metformin and group B received regular insulin. Patient was admitted at 36 wks onwards. Neonatal hypoglycemia was measured and entered in structured Performa. All the data was entered and analyzed through SPSS version 22.

Results: In this study, the mean ± sd ages of patients were 28.7±5.05 years in insulin group while 28.01±4.37years in metformin group. Mean neonatal blood sugar level was 51.58±11.77mg/dl in insulin group while 57.37±10.61mg/dl in metformin group. The difference was significant (p<0.05). In this study, neonatal hypoglycemia was noted in 28 (23.3%) cases with insulin while in 1 (0.8%) case with metformin. The difference was significant (p<0.05).

Conclusion: Metformin has better outcome than insulin in terms of less number of neonatal hypoglycemia.

Key words: Gestational Diabetes, Metformin, Insulin, Neonatal Hypoglycemia