Aim: To understand the psychological impact of COVID – 19 on Medical Students of a private sector Medical University in Karachi, Pakistan.

Method: This cross-sectional study was conducted among medical students studying at Hamdard College of Medicine and Dentistry, Karachi, Pakistan. The data collection was done through online survey from July 2020 to December  2020. The study aimed to gather data from many medical students. A total number of 420 students were participated from Hamdard College of Medicine and Dentistry in Karachi, Pakistan. The participants were selected from all years of MBBS and BDS programs .

Results: Out of 420 participants, 236 (56.2%) were male and 184 (43.8%) female, with a male:female ration of 1.28:1. Majority of participants were single as 411 (97.9%), of 224 (53.3%) students living with their family, 150 (35.7%) in hostel and 46 (11%) living with friends. In our sample 369 (87.9%) students studying in MBBS program while only 51 (12.1%) BDS, among those 80 (19%) medical students were in first year, followed by 122 (29%) second year, 65 (15.5%) third year, 54 (12.9%) fourth year and 99 (23.6%) studying in final year. IES-R scale and results shows 75 (17.9%) reported that PTSD is a clinical concern, probable diagnosis of PTSD 28 (6.7%) and majority rated as high enough to PTSD 133 (31.7%). Impact of event (revised) scale shows significant association with age and year of study with p value 0.026 and 0.002 respectively. Based on the PHQ9 scale, Gender, Living arrangements and the program enrolled in were reported significant association with depression p values 0.059, 0.008 and 0.006 respectively.

Conclusion: Findings suggests high rate of anxiety, depression, and signs of PTSD in medical students due to COVID-19 which needs pressing attention and provision of professional help from mental health practitioners.

Keywords: Impact, Covid-19, Medical students