Background: Tuberculosis is a contagion from ancient times comprising around one 3^rd of global population on the wedge of infection with Mycobacterium tuberculosis complex where under developed and developing countries is coping with high burden of the disease.

Aim: To observe the most prevalent occupation and treatment outcome in both Genders of MDR TB patients.

Methodology: Health Research Institute-National Institute of Health TB Research Centre in collaboration with Department of Pulmonology, King Edward Medical University/Mayo Hospital Lahore from january 2014 to December 2020. A pre-designed questionnaire was used to collect data from MDR Tb patients after verbal informed consent. Patients were followed to see the final outcome on completion of anti-tubercle treatment. Data was entered and analyzed by using SPSS.

Results: Out of total 450 MDR TB patients analyzed in this study a higher proportion of 54.9% were males and 45.1% were females with an overall mean age of patients as 39.64±17.52 years. Most of 159(35.4%) patients had no skills and were labors whereas most of 145 (28.2%) females were house wives. Almost 71% of the patients successfully completed the treatment including 45% cured on the basis of availability of final smear and culture reports..

Conclusion: A high mortality rate of MDR TB patients was observed while most of the TB patients in this study belong to labor class while most of the women were housewives.

Keywords: Tuberculosis, MDR TB, Occupation, Treatment outcome, loss to follow up.