The clinical alarms are used to enhance safety by alerting care provider to any deviations from normal status. The alarms alert care provider when there is deterioration in patient’s condition and there is a need for intervention, or when a device is not working as it should (1).

Objectives:The aims of present study is to find out the effectiveness of instruction program on nurses knowledge about the clinical devices alarm, and to find out the relationship between the effectiveness of program and nurses level of education, year of experiences in nursing, and year of experiences in intensive care units.

Methodology: a quasi-experimental study wascarried out on 80 nurses is divided to two groups (Experimental group who exposed on program, and control group to compare with experimental group) two group of nurse is workingin Al-Imam Al-Hussein Medical City, in holy Kerbala’a City, Iraq. The study started at 3rd of May, 2020 to 25th of May, 2021.The instrument consist of two part; part one deals the characteristics of the sample which of age, gender, level of education, year of experiences in nursing, year of experiences in intensive care units, and specific training course. Part two deals the nurses knowledge related to clinical devices alarm which of 30 items, the validity of instrument and program was obtained from 12 expert in specialty, the reliability was =1.81, the data analysis was done by uses SPSS program version 23, the statistical methods which used in present study is descriptive and inferential statistics.

Results: the findings of present study revealed that the correct answer for experimental group at pretest was 42.44% then at post test was 99.87%, and correct answer for control group was 31.71 at pretest and 35.69% at post test., and there were statistical differences between experimental and control group at post test at P≤0.05

Conclusions:the study concluded that the instruction program on nurses knowledge was effective on experimental group through improving their knowledge

Recommendations:The researchers recommend that the current program should be applied to all nurses in critical units because of its utmost importance in monitoring and patient safety.

Keywords:Effectiveness, InstructionsProgram,Nurses, Knowledge, Clinical, Monitoring, Devices, Alarms, Intensive Care Unit