Needle sticks injury considerably affects nurse’s wellbeing while performing routine patient’s care. Thus, nurses are at risk of exposure to various kinds of infectious diseases.

Objectives: To analyze the practice of nurses regarding prevention from needle stick injury in Tertiary Care Hospitals of Lahore.

Study Design: Cross-sectional study.

Methodology: Study setting was tertiary care hospitals of Lahore, Pakistan after ethical review committee’s (ERC) approval. Data was collected from nurses by using tool used in this study was check list for observation of Nurses practice related to sharps and needles. This check list contains fourteen criteria for observation of Nurses’ practice. Whether they were doing; yes or no. sel. convenient sampling technique was used, and sample size was 93.

Statistical analysis: SPSS 21 was utilized for the data analysis.

Results: It was observed that 03(3%) Nurses were performing Safe Needle Handling Technique in procedure room while 90(97%) Nurses were not performing it. It was observed that 91(98%) Staff Nurses wash hands before and after use of syringes while only 02(2%) Nurses were not performing it.

Conclusion: We concluded that nurses have ignorance of the protocols become the reason of such incidents even now. It is the need of time to implement appropriate strategies for precaution and intervention through hospital administration to avoid the needle stick injuries.

Key Words: Needle Stick Injury, Re-capping of needles and Knowledge