Background: The knowledge of pregnant women about cosmetics' dangers is still shallow; this is because pregnant women mostly have never consulted a dermatologist regarding the cosmetic products they use.

Aim: This study aimed to determine the relationship between pregnant women's knowledge about cosmetics and the use of facial cream.

Method: This research applied an analytical survey with a cross-sectional approach. The study samples were 40 pregnant women taken from a population of 44 pregnant women who used facial cream with Slovin formula and a purposive sampling technique that met the inclusion criteria. The instrument used questionnaires.

Results: Data analyzed by the Chi-Square test showed bivariate results (ρ = 0.001) <0.05 indicating that there were relationships between 2 variables.

Conclusion: In conclusion, there was a relationship between maternal knowledge about cosmetics and the use of facial cream in the Bre Village of Palibelo Primary Health Center in 2017.

Keywords: Knowledge, Pregnant women, Cosmetics