Background: In Indonesia, in 2012, there were 39.8 million fertile age couples, 10-15% of whom were declared infertile. Infertility often develops into a social problem because the wife is considered to be the cause. Coping mechanisms are used in dealing with stress infertility.

Aim: This study aims to determine the relationship between coping mechanisms and stress levels in childbearing women with infertility at PKU Muhammadiyah Yogyakarta Hospital.

Method: Research design using cross-sectional. The sampling technique with total sampling found 38 female respondents of childbearing age with infertility—data collection with DASS 42 instrument and Brief Cope 28. Data analysis used Kendall's tau.

Results: The results showed that the p-value was 0.002 <0.005, and the Correlation Coefficient value was 0.516.

Conclusion: There is a relationship between coping mechanisms and stress levels in childbearing women with infertility at PKU Muhammadiyah Yogyakarta Hospital with moderate closeness.

Keywords: coping mechanisms, infertility, stress level