Objective: To evaluate the functional outcome of extra-articular fracture of distal femur, LISS plating versus retrograde intramedullary interlocking nailing.

Study Design: Prospective/Randomized control trial

Place and Duration of Study: Department of Orthopaedic Surgery, Ghulam Muhammad Mahar Medical College Sukkur from 1st July 2019 to 31st December 2020.

Methodology: One hundred patients of both genders with ages 20 to 60 years presented with fractures of distal femur were included in this study. Patients were equally divided into two groups I and II. Group I contained 50 patients and received LISS plating and Group II contained 50 patients and received closed retrograde intramedullary interlocking nail, Pre and post-operative assessment was done. Post-operative complications were noted at 12th day. Functional outcomes were examined after 6 months by the NEERs criteria.

Results: Sixty five (65%) patients were males (35 in group I and 30 in group II) and 35 (35%) patients were females (15 in group I and 20 in group II). Road traffic accident was the most common mode of injury in 62 (62%) patients. Most of the fractures were on right side 66 (66%). According to the NEER criteria, 80% patients shows excellent, 20% patients shows satisfactory with no poor results in Group I and in Group II 30% patients shows excellent, 66% patients shows satisfactory results and 4% shows unsatisfactory results.

Conclusion: The LISS plating and closed retrograde intramedullary interlocking nail was safe and effective methods for extra-articular fractures of distal femur but there were less complications found in LISS plating.

Keywords: Fracture of distal femur, LISS plating, Interlocking nail