ABSTRACT

Introduction: Postpartum hemorrhage is one of the main causes of morbidity and mortality in pregnant mothers. Some studies have used tranexamic acid before delivery. This medication has been found to be useful in reducing postpartum hemorrhage. Therefore, the aim of this study was to investigate the effect of tranexamic acid before hemorrhage in mothers without risk factors.

Materials and Methods: This double-blind clinical trial study was conducted on 100 pregnant women admitted to the labor ward of Besat Hospital in Sanandaj during November 2020 to March 2021. Participants were randomly selected and divided into two groups of receiving tranexamic acid (intervention) and placebo (control). Finally, outcomes such as maternal age, gestational age, body mass index, postpartum hemorrhage, hemoglobin depletion, hematocrit depletion, thromboembolism and drug allergy were studied in both groups.

Results: Between the two groups, the rate of hemoglobin depletion, hematocrit depletion and postpartum hemorrhage in the group that received tranexamic acid in the active phase of labor was lower than the group that did not receive tranexamic acid (for all three cases P <0.001). Also, none of the patients developed thromboembolism and drug allergy following receiving tranexamic acid (P> 0.05).

Conclusion: During the active phase of labor, if tranexamic acid is prescribed to prevent severe postpartum hemorrhage, it can be effective in reducing postpartum hemorrhage.

Keywords: Tranexamic Acid, Postpartum Hemorrhage, Prophylaxis