ABSTRACT

To know the effect of the contraceptive pills on liver enzymes GOT, GPT in infected mice with visceral Leishmaniasis, ingested orally with the pills with a dose 0.012 mg/day and comparisons with pentostam drug 0.4 mg/day treated with 21 days. The results showed that the pills led to a significant increase in GOT and GPT in the third weeks, compared to the pentostam group. It could be concluded that the contraceptive pills had a clear role in increasing the severity of the parasite infection in the laboratory animals by the observed increase in these physiological indicators.

Keywords: leishmania donovani, the contraceptive pills, liver enzymes GOT, GPT.