ABSTRACT

Aim: To determine the changes in the coagulation profile, fibrinogen level and anti-thrombin level in females on hormonal OCPs.

Methodology: This case control study was carried out at Family planning and fertility clinics, of three hospitals of Lahore. Females of age 16-49 years using hormonal contraceptives for at least 6 months were included in case group. In control group, 55 females matched for age who are not taking hormonal contraceptives were taken. PT, APTT and fibrinogen assay and anti-thrombin level estimation was done using standard laboratory procedures.

Results: The mean of age was 29.02+5.81 years, hemoglobin 11.74+0.96mg/dl, platelets 316.43+47.04, prothrombin is 11.76+0.922%, fibrinogen is 2.643+0.45g/L and antithrombin level is 87.36+5.71%. Haemoglobin levels were better in group not using hormonal contraceptive and a significant relationship between shortening of PT, APTT, increase in fibrinogen level and decrease in antithrombin level with hormonal contraceptives than controls.

Conclusion: Hormonal contraceptives are most commonly used method, but its effects on coagulation profile cannot be ignored. Prothrombin time and APTT were decreased, mild increase in fibrinogen but considerable lowering of antithrombin levels. We must educate about non-hormonal contraceptive method to minimize the risk.

Keywords: Contraceptives, Antithrombin level, APTT, Fibrinogen time, Thrombosis