ABSTRACT

Aim: To determine the insulin resistance in type 2 diabetic male and female patients and to compare Insulin resistance in type 2 diabetic males with type 2 diabetic females

Study design: Cross-sectional study

Place and duration of Study: Department of Medicine Unit 4, Services Institute of Medical Sciences, Lahore from 1^st June 2020 to 30^th November 2020.

Methodology: One hundred and forty patients of both genders with age ranging between 25 to 65 years were included by non-probability sampling. Patients demographics details like age, gender and body mass index were recorded after taking written informed consent. Insulin and serum glucose levels were observed at fasting state amongst patients. HOMA-IR was used to calculate IRI (insulin resistance indices) in patients.

Results: Mean age of the patients was 38.14±8.39 years with mean BMI 22.41±4.22 kg/m². Sixty-three (45%) were males and majority 77 (55%) cases were females. Serum glucose levels in males were increased 12.84±7.98 mmol/L and insulin resistance were 6.51±9.113 as compared to females10.48±12.64 mmol/L with insulin resistance indices5.48±3.148. Statistically no difference was observed with respect to gender (p<0.005).

Conclusion: In our study, no comparative difference is found in insulin resistance of Type 2 diabetic males and females. Further larger scale studies with larger sample size including genetic data are required to address whether confounding variables are influencing gender variation in insulin resistance or not.

Keywords: Diabetic type 2, Insulin resistance, Hyperglycemia, Hyperinsulinemia