ABSTRACT

Background: Chorioamnionitis or intra-amniotic infection is an acute inflammation of the membranes and chorion of the placenta, typically due to ascending poly-microbial bacterial infection in the setting of membrane rupture. The infection can occur when bacteria that are normally present in the vagina ascend into the uterus, where the fetus is located.

Aim: To determine the diagnostic accuracy of C-reactive protein for diagnosis of chorioamnionitis in patients presenting with premature rupture of membranes near term taking histopathology as gold standard.

Methods: It was cross sectional study conducted in Gynecology and Obstetrics Unit II, Services Hospital Lahore for duration of 6 months from 31-8-2019 to 5-3-2020. Total 148 females who fulfilled selection criteria was enrolled in this study from emergency. Blood sample was collected and sent to the laboratory of the hospital for assessment of CPR level. Reports were assessed and if CRP. If CRP>6ml, then patients were labeled as positive. Then patients underwent delivery through cesarean section. Placenta and amniotic membranes were sent for histopathological evaluation.

Results: The average age of women was 26.8 2± 2.98 years. Mean gestational age of women in this study was 39.15±1.41 weeks. Sensitivity and specificity of CRP was 86.84% and 85.29% respectively while PPV and NPV was 95.19% and 65.91% respectively, overall diagnostic accuracy was 86.49%.

Conclusion: C-reactive protein for diagnosis of chorioamnionitis has diagnostic accuracy of 86.49% in patients presenting with PROM near term taking histopathology as gold standard.

Keywords: Diagnostic, Accuracy, C-reactive protein, Chorioamnionitis, premature, Rupture, Membranes.