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Aim: The current study aimed to study the effect of nursing protocol in insertion and care of Vascular Access Devices (VAD) in oncology pediatric patients

Design: A quasi experimental design was used.

Setting: This study was conducted at the oncology department Unit, affiliated to Ain Shams University Hospital and police hospital at El-Agoza.

Sample: A purposive example of (50) nurses were working at Ain Shams and (20) at ElAgoza. I. Predesigned Questionnaire Format, Assessment tool for the studied children , Questionnaire tool for nurses to assess nurse's knowledge, Observational checklists used to assess the nurses' practices regarding nursing protocols for care and insertion of VAD

Results: there was positive correlation between knowledge of the studied nurses and their total practices and regarding vascular access devices (Port-A-Cath, Hickman, and CVC) throughout intervention with statically significant differences (p<0.05).

Conclusion: Implementation of the nursing protocol has statistically significant positive effect in insertion and care of VAD on oncology pediatric patients

Recommendation: the nursing protocol should be applied for all nurses who deal with pediatric devices.

Keywords: Nursing Protocol, Vascular Access Devices, Oncology, Pediatric Patients