ABSTRACT

Aim: To study hyponatremia with portosystemic encephalopathy (PSE). Study Design: Cross sectional study Place of study: Department of gastroenterology Hayatabad medical complex, Peshawar Methodology: This was a cross sectional study that was done in Department of gastroenterology Hayatabad Medical Complex, Peshawar after approval from the hospital ethical committee. Total of 420 patients with Portosystemic Encephalopathy (PSE) were included.

Results: Out of 420 cases, 252 cases were males and 168 were females. Mean± SD of age was 61±0.22 and Mean ± SD of serum sodium level was 126±0.19. 178 patients were having sodium level between 120--125mmol/l i.e. severe hyponatremia (Grade III and IV Portosystemic encephalopathy). Patients having sodium level between 126--130mmol/l were 212 (Grade II and III portosystemic encephalopathy).

Conclusion: Hyponatremia was frequently found in patients with portosystemic encephalopathy and sodium levels were inversely related to the grades of portosystemic encephalopathy i.e. patients having severe hyponatremia i.e. <125mmol/l were in higher Grades of encephalopathy i.e. Grade III and IV and vice versa.

Keywords: portosystemic encephalopathy, Hyponatremia, chronic liver disease