ABSTRACT

Aim: To compare the efficacy of Dapagliflozin in combination with Metformin versus Sitagliptin in type 2 diabetic patients.

Design of study: Controlled randomized study in department of Medicine, DHQ Hospital, Sahiwal for six months i.e. 05-05-2019 to 05-11-2019

Methodology: 220 subjects were selected via OPD of DHQ Hospital, Sahiwal. Patients were randomly divided into two groups. In Group-A, patients were given 100mg q.d sitagliptin plus 850 mg metformin twice a day. In Group-B, patients were given 10mg qd dapagliflozin plus 850mg metformin twice a day. Patients were followed up in OPD for 24 weeks. After 24 weeks, blood sample was obtained for assessment of HbA1c. Reports were assessed and if HbA1c is < 7.0 then efficacy achieved. All this information was recorded on Performa.

Results: Efficacy of dapagliflozin and metformin versus sitagliptin and metformin in type 2 diabetes mellitus patients shows that 39(35.5% in Group A and 28(25.5%) in Group-B had efficacy and p value was 0.10.

Conclusion: Efficacy of Metformin and Dapagliflozin is not significantly different when compared with Metformin and Sitagliptin in Diabetes Mellitus Type 2 patients

Keywords: Type 2 diabetes mellitus, Dapagliflozin, Metformin, Sitagliptin