ABSTRACT

Every year, a large number of deaths are due to the complications of fibrosis. Fibrosis is an important and unanticipated health problem around the world that has not only medical but also economical costs to the global economy. Pathologically, fibrosis is caused by the proliferation and activation of fibroblasts and myofibroblasts and excessive deposition of extracellular matrix (ECM) components in organs and tissues. In all forms of fibrosis, inflammatory-immunological reactions occur in the early stages, and components of the innate immune have a role in confronting fibrosis. Vitamin D has anti-fibrosis functions, regulates cell proliferation and differentiation, regulates anti-inflammatory elements, and regulates the immune system, therefore, serum levels of 1,25 (OH) 2D3 may be negatively associated with the progression of fibrosis; In fact, Vitamin D causes this by inhibiting TGF-β. In this review study, we intend to investigate the achievements of various studies in this field.

Keywords: Vitamin D, TGF-β, Advanced fibrosis, Vitamin D deficiency, TGF-β cellular receptor