ABSTRACT

Background: Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infection (STI) globally. The WHO estimates 131 million new C. trachomatis genital infection cases occur annually. Aim: To detect Chlamydia Trachomatis Antibodies among infertile women who had Assisted Reproduction Technology (ART), find the relation between seropositivity and age, duration of mirage,failure ofART, and severity of the disease. Methods: This was a case-control study conducted in Elsir Abu El-Hassan Fertility Center, Khartoum,Sudan, from October 2018 - May 2019. Ninety women were enrolled( Sixty women with ART failure (cases) and thirty women had successful ART (control)); their ages ranged from 20 to 50 years with 31 years mean. Anti-Chlamydia Trachomatis Antibodies were tested in serum specimens through enzyme-linked immunosorbent assay (ELISA). Data was collected and analyzed with the SPSS program, version 21. Results: Out of the total of 60 infertile women with recurrent ART failure, 4(6.7%) were positive for Chlamydiae IgG, while all the control group was negative. Regarding IgM antibodies, All participants were negative. Out of total IgG positive, 75% belonged to (30-40) age group, and 50% were married for less than five years.75% of them committed ART one time. Statistical analysis revealed no relation between IgG seropositivity and ART succeed(P =0.1) (having kids (P=0.3), age (P=0.4), duration of marriage(P=0.2), and number of ART (P=0.8). Conclusion: Seroprevalence of Chlamydia Trachomatis infection is prevalent among infertile women with recurrent ART failure;there is no relation between Chlamydia infection and ART's recurrent failure. Keyword: Chlamydia Trachomatis, ELISA, ART, Infertile women